儿童原发性胃食管反流和牛奶蛋白过敏相关性胃食管反流时的血清胃泌素浓度。

Serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy.

机构信息

Department of Pediatrics, Pediatric Gastroenterology and Allergology, Medical University of Bialystok, Bialystok, Poland.

出版信息

Adv Med Sci. 2011;56(2):186-92. doi: 10.2478/v10039-011-0053-8.

DOI:10.2478/v10039-011-0053-8

PMID:22112435

Abstract

PURPOSE

The assessment of the serum gastrin concentrations and the role of enterohormone in children with primary acid gastroesophageal reflux (GER) and GER secondary to cow's milk allergy (CMA).

MATERIALS/METHODS: 138 children were diagnosed with pathological acid GER on the basis of pH-metric examination. 76 (28.8%) patients had primary GER and 62 (23.5%) patients had GER secondary to CMA.Serum gastrin concentration (fasting and postprandial) was assessed before treatment and 1 and 2 years after initiation of the therapy.

RESULTS

The children with primary GER had the fasting gastrin concentration 69.46 ± 11.87 μU/ml before treatment, 77.86 ± 26.35 μU/ml after 1 year and 83.78 ± 25.21 μU/ml after 2 years of treatment. The children with GER secondary to CMA had gastrin concentrations 89.61 ± 26.75, 73.17 ± 19.49 and 73.90 ± 20.31 μU/ml respectively. The mean postprandial gastrin concentration after treatment was higher than before treatment in children with both primary and secondary GER. The primary GER group had postprandial gastrin concentration 96.07 ± 33.51 μU/ml before treatment and 116.06 ± 33.95 μU/ml and 118.48 ± 33.96 μU/ml after 1st and 2nd year of therapy respectively. The secondary GER group had postprandial gastrin concentration 85.33 ± 14.12 μU/ml before treatment and 106.55 ± 24.51 μU/ml and 110.36 ± 24.67 μU/ml after 1st and 2nd year of therapy respectively.

CONCLUSIONS

The mean fasting serum gastrin concentrations in patients with primary and secondary GER were similar and mean postprandial concentrations were higher than fasting concentrations in both study groups.

摘要

目的

评估胃泌素浓度在儿童原发性胃酸胃食管反流（GER）和牛奶过敏（CMA）继发 GER 中的作用。

材料/方法：根据 pH 测量检查，138 名儿童被诊断为病理性酸 GER。76 名（28.8%）患者为原发性 GER，62 名（23.5%）患者为 CMA 继发 GER。治疗前、治疗后 1 年和 2 年分别评估空腹和餐后血清胃泌素浓度。

结果

原发性 GER 患儿治疗前空腹胃泌素浓度为 69.46±11.87μU/ml，治疗后 1 年为 77.86±26.35μU/ml，2 年为 83.78±25.21μU/ml。CMA 继发 GER 患儿的胃泌素浓度分别为 89.61±26.75、73.17±19.49 和 73.90±20.31μU/ml。治疗后，原发性和继发性 GER 患儿的餐后平均胃泌素浓度均高于治疗前。原发性 GER 组治疗前餐后胃泌素浓度为 96.07±33.51μU/ml，治疗后 1 年和 2 年分别为 116.06±33.95μU/ml和 118.48±33.96μU/ml。继发性 GER 组治疗前餐后胃泌素浓度为 85.33±14.12μU/ml，治疗后 1 年和 2 年分别为 106.55±24.51μU/ml和 110.36±24.67μU/ml。