The University of Texas M.D. Anderson Cancer Center, Division of Pathology & Laboratory Medicine, Houston, TX, USA.
Cancer Biomark. 2010;9(1-6):159-76. doi: 10.3233/CBM-2011-0175.
Bladder cancer originates in the epithelial lining of the bladder's mucosa and develops in association with several habitual, industrial, and environmental risk factors via papillary and non-papillary pathways. In this chapter we review novel concepts concerning the molecular mechanisms of early field change in bladder neoplasia stemming from whole-organ genomic mapping studies. These mechanisms are discussed in the context of molecular pathogenesis of bladder cancer and in relation to treatment and biomarker-based detection strategies.
膀胱癌起源于膀胱黏膜的上皮衬里，并通过乳头状和非乳头状途径与几种习惯性、工业和环境风险因素相关发展。在本章中，我们回顾了源于全器官基因组图谱研究的有关膀胱癌早期领域变化的分子机制的新观念。这些机制在膀胱癌的分子发病机制的背景下进行讨论，并与治疗和基于生物标志物的检测策略相关。
