Department of Neurosurgery, Royal Free Hospital NHS Trust, Pond Street, London NW3 2QG, UK.
Ultrasonics. 2012 Mar;52(3):364-76. doi: 10.1016/j.ultras.2011.07.001. Epub 2011 Jul 8.
Identification of the anatomical location and mechanical properties such as adherence at the tissue tumour interface may be of clinical benefit in determination of tumour resectability and prognosis. There are currently no imaging modalities in routine clinical practice that can provide this information. This paper presents the development of a new imaging technique based on ultrasound elastography, called slip elastography, for determination of the anatomical location and measurement of the adherence between two surfaces. The theoretical basis of slip and its definition in relation to shear are described. In vitro testing with gelatine phantoms to determine the optimal parameters for shear strain estimation and slip boundary measurement and to test reliability are also described. The results suggest that slip elastography can reliably identify the anatomical location of a slip boundary and can measure the externally applied axial force required to initiate slip at that boundary in vitro. The vector based shear strain estimator was the most robust and worked with minimal angular dependence with minimal non-slip shearing artefact.
确定组织肿瘤界面的解剖位置和机械特性（如粘附性）可能对确定肿瘤可切除性和预后具有临床意义。目前，常规临床实践中没有可以提供这些信息的成像方式。本文介绍了一种新的基于超声弹性成像的成像技术，称为滑移弹性成像，用于确定两个表面之间的解剖位置和测量粘附。描述了滑移的理论基础及其与剪切的关系定义。还描述了使用明胶体模进行的体外测试，以确定用于估计剪切应变和滑移边界测量以及测试可靠性的最佳参数。结果表明，滑移弹性成像可以可靠地识别滑移边界的解剖位置，并可以测量在体外起始滑移所需的外部施加的轴向力。基于向量的剪切应变估计器是最稳健的，具有最小的角度依赖性，并且具有最小的非滑移剪切伪影。
