Departmento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Carretera de Sacramento s/n, La Cañada de San Urbano, 04120 Almeria, Spain.
Psychopharmacology (Berl). 2012 Jan;219(2):647-59. doi: 10.1007/s00213-011-2570-3. Epub 2011 Nov 24.
Schedule-induced polydipsia (SIP), characterized by the development of excessive drinking under intermittent food-reinforcement schedules, has been proposed as a successful model for obsessive-compulsive disorder (OCD), schizophrenia, and alcohol abuse.
The purpose of this study was to review the main findings and current thinking regarding the use of SIP for compulsivity assessment and evaluate its contribution to improving our knowledge of the neurobehavioral mechanisms underlying the excessive behavior manifested in SIP relevant to compulsive behavior disorders.
The literature reviews SIP procedure and surveys main findings about its neurobehavioral basis and pharmacology relevant to its possible status as a model for compulsive disorders. Specifically, we reviewed effects of antipsychotics and serotoninergic drugs used in the treatment of OCD and schizophrenia. We also considered individual differences in SIP and its relevance as a possible compulsivity endophenotype.
SIP represents an animal model of non-regulatory and excessive drinking that may be valid for studying the psychopharmacology of the compulsive phenotype and modeling different psychopathologies from compulsivity spectrum disorders.
间歇性食物强化程序诱发的多饮（SIP）的特征是在间歇性食物强化程序下发展出过度饮酒，被提议作为强迫症（OCD）、精神分裂症和酒精滥用的成功模型。
本研究的目的是回顾关于 SIP 用于评估强迫性的主要发现和当前思路，并评估其对我们了解 SIP 相关过度行为的神经行为机制的贡献，这些过度行为与强迫性行为障碍有关。
文献回顾了 SIP 程序，并调查了其神经行为基础和与强迫症相关的药理学的主要发现，特别是我们回顾了抗精神病药和用于治疗 OCD 和精神分裂症的血清素能药物的作用。我们还考虑了 SIP 的个体差异及其作为可能的强迫性内表型的相关性。
SIP 代表一种非调节性和过度饮酒的动物模型，可能对研究强迫表型的精神药理学以及建模不同的精神病理学从强迫性谱系障碍有价值。
