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从营养模式到行为：高脂饮食对大鼠抑制控制、脑基因表达和代谢组学的影响

From Nutritional Patterns to Behavior: High-Fat Diet Influences on Inhibitory Control, Brain Gene Expression, and Metabolomics in Rats.

作者信息

Ruiz-Sobremazas Diego, Abreu Ana Cristina, Prados-Pardo Ángeles, Martín-González Elena, Tristán Ana Isabel, Fernández Ignacio, Moreno Margarita, Mora Santiago

机构信息

Center for Welfare and Social Inclusion of the University of Almeria, Crta. Sacramento s/n, La Cañada de San Urbano 04120, Spain.

Department of Psychology and Sociology, University of Zaragoza, Crta. Atarazana 4, Teruel 44003, Spain.

出版信息

ACS Chem Neurosci. 2024 Dec 18;15(24):4369-4382. doi: 10.1021/acschemneuro.4c00297. Epub 2024 Nov 28.

DOI:10.1021/acschemneuro.4c00297
PMID:39607956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11660154/
Abstract

Impulsive and compulsive behaviors are associated with inhibitory control deficits. Diet plays a pivotal role in normal development, impacting both physiology and behavior. However, the specific effects of a high-fat diet (HFD) on inhibitory control have not received adequate attention. This study aimed to explore how exposure to a HFD from postnatal day (PND) 33 to PND77 affects impulsive and compulsive behaviors. The experiment involved 40 Wistar rats subjected to HFD or chow diets. Several tasks were employed to assess behavior, including variable delay to signal (VDS), five choice serial reaction time task (5-CSRTT), delay discounting task (DDT), and rodent gambling task (rGT). Genetic analyses were performed on the frontal cortex, and metabolomics and fatty acid profiles were examined by using stool samples collected on PND298. Our results showed that the HFD group exhibited increased motor impulsive behaviors while not affecting cognitive impulsivity. Surprisingly, reduced impulsive decision-making was shown in the HFD group. Furthermore, abnormal brain plasticity and dopamine gene regulation were shown in the frontal cortex, while metabolomics revealed abnormal fatty acid levels.

摘要

冲动和强迫行为与抑制控制缺陷有关。饮食在正常发育中起着关键作用，影响生理和行为。然而，高脂饮食（HFD）对抑制控制的具体影响尚未得到充分关注。本研究旨在探讨从出生后第33天（PND）到第77天暴露于高脂饮食如何影响冲动和强迫行为。实验涉及40只接受高脂饮食或普通饮食的Wistar大鼠。采用了多项任务来评估行为，包括可变信号延迟（VDS）、五选择串行反应时任务（5-CSRTT）、延迟折扣任务（DDT）和啮齿动物赌博任务（rGT）。对额叶皮质进行了基因分析，并使用在PND298收集的粪便样本检查了代谢组学和脂肪酸谱。我们的结果表明，高脂饮食组表现出运动冲动行为增加，而不影响认知冲动性。令人惊讶的是，高脂饮食组的冲动决策减少。此外，额叶皮质显示出异常的脑可塑性和多巴胺基因调节，而代谢组学揭示了脂肪酸水平异常。

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本文引用的文献

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Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors.滋养大脑：营养物质对认知、突触功能和 AMPA 受体的影响。
Nutrients. 2022 Oct 5;14(19):4137. doi: 10.3390/nu14194137.
2
NMR-based Metabolomics and Fatty Acid Profiles to Unravel Biomarkers in Preclinical Animal Models of Compulsive Behavior.基于核磁共振的代谢组学和脂肪酸谱分析以揭示强迫行为临床前动物模型中的生物标志物
J Proteome Res. 2022 Mar 4;21(3):612-622. doi: 10.1021/acs.jproteome.1c00857. Epub 2022 Feb 10.
3
Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice.
饱和脂肪和不饱和脂肪饮食可损害青春期小鼠海马谷氨酸能传递。
Psychoneuroendocrinology. 2021 Nov;133:105429. doi: 10.1016/j.psyneuen.2021.105429. Epub 2021 Sep 24.
4
Long-term high fat diet consumption reversibly alters feeding behavior via a dopamine-associated mechanism in mice.长期高脂肪饮食通过与多巴胺相关的机制在小鼠中可逆地改变摄食行为。
Behav Brain Res. 2021 Sep 24;414:113470. doi: 10.1016/j.bbr.2021.113470. Epub 2021 Jul 16.
5
The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach.内源性大麻素系统在大鼠饮食诱导肥胖后在奖励和稳态脑区中被调节：一种聚类分析方法。
Eur J Nutr. 2021 Dec;60(8):4621-4633. doi: 10.1007/s00394-021-02613-0. Epub 2021 Jun 24.
6
Diet-induced obesity leads to alterations in behavior and gut microbiota composition in mice.饮食诱导的肥胖会导致小鼠行为和肠道微生物组成发生改变。
J Nutr Biochem. 2021 Jun;92:108622. doi: 10.1016/j.jnutbio.2021.108622. Epub 2021 Mar 8.
7
Facets of Impulsivity in Relation to Diet Quality and Physical Activity in Adolescence.青少年冲动特质与饮食质量和身体活动的关系。
Int J Environ Res Public Health. 2021 Jan 12;18(2):613. doi: 10.3390/ijerph18020613.
8
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9
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Physiol Behav. 2021 Feb 1;229:113260. doi: 10.1016/j.physbeh.2020.113260. Epub 2020 Nov 20.
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Diet, inflammation and the gut microbiome: Mechanisms for obesity-associated cognitive impairment.饮食、炎症与肠道微生物组：肥胖相关认知障碍的发生机制。
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