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3-乙烯硫基和3-乙烯硫甲基头孢烯衍生物的合成及其生物活性

Synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives.

作者信息

Nishimura S, Yasuda N, Sasaki H, Kawabata K, Sakane K, Takaya T

机构信息

New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1990 Sep;43(9):1160-8. doi: 10.7164/antibiotics.43.1160.

DOI:10.7164/antibiotics.43.1160
PMID:2211378
Abstract

The synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. Both series possess potent antibacterial activity. Among them, 3-[(Z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum.

摘要

描述了一些3-乙烯硫基和3-乙烯硫基甲基头孢烯衍生物的合成及生物学性质。这两个系列都具有强效抗菌活性。其中，3-[(Z)-2-氰基乙烯硫基甲基]头孢烯衍生物具有较广的抗菌谱。

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