Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.
ChemMedChem. 2012 Jan 2;7(1):22-31. doi: 10.1002/cmdc.201100404. Epub 2011 Nov 24.
For more than 50 years dequalinium chloride has been used successfully as an antiseptic drug and disinfectant, particularly for clinical purposes. Given the success of dequalinium chloride, several series of mono- and bisquaternary ammonium compounds have been designed and reported to have improved antimicrobial activity. Furthermore, many of them exhibit high activity against mycobacteria and protozoa, especially against plasmodia. This review discusses the structure-activity relationships and the modes of action of the various series of (bis)quaternary ammonium compounds.
五十多年来，盐酸双胍己烷已成功用作防腐剂和消毒剂，尤其在临床应用方面。鉴于盐酸双胍己烷的成功，人们设计并报道了几类单季铵和双季铵化合物，据称它们具有增强的抗菌活性。此外，其中许多化合物对分枝杆菌和原生动物，特别是疟原虫，具有很高的活性。本文讨论了不同系列（双）季铵化合物的构效关系和作用模式。
