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基于季铵盐的材料：在海洋和水处理工业中环境毒性、防污机制和应用的综述。

Quaternary Ammonium Salts-Based Materials: A Review on Environmental Toxicity, Anti-Fouling Mechanisms and Applications in Marine and Water Treatment Industries.

机构信息

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, Italy.

Sustainable Mobility Center (Centro Nazionale per la Mobilità Sostenibile-CNMS), Via Durando 39, 20158 Milano, Italy.

出版信息

Biomolecules. 2024 Aug 7;14(8):957. doi: 10.3390/biom14080957.

DOI:10.3390/biom14080957
PMID:39199346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352365/
Abstract

The adherence of pathogenic microorganisms to surfaces and their association to form antibiotic-resistant biofilms threatens public health and affects several industrial sectors with significant economic losses. For this reason, the medical, pharmaceutical and materials science communities are exploring more effective anti-fouling approaches. This review focuses on the anti-fouling properties, structure-activity relationships and environmental toxicity of quaternary ammonium salts (QAS) and, as a subclass, ionic liquid compounds. Greener alternatives such as QAS-based antimicrobial polymers with biocide release, non-fouling (i.e., PEG, zwitterions), fouling release (i.e., poly(dimethylsiloxanes), fluorocarbon) and contact killing properties are highlighted. We also report on dual-functional polymers and stimuli-responsive materials. Given the economic and environmental impacts of biofilms in submerged surfaces, we emphasize the importance of less explored QAS-based anti-fouling approaches in the marine industry and in developing efficient membranes for water treatment systems.

摘要

致病微生物对表面的附着及其形成抗生素耐药生物膜的关联，威胁着公共健康，并对多个工业部门造成重大经济损失。出于这个原因，医学、制药和材料科学界正在探索更有效的防污方法。本综述重点介绍了季铵盐（QAS）及其亚类离子液体化合物的防污特性、结构-活性关系和环境毒性。我们还介绍了具有杀菌释放、非污（即 PEG、两性离子）、防污释放（即聚二甲基硅氧烷、氟碳）和接触杀伤特性的基于 QAS 的抗菌聚合物等绿色替代品。鉴于水下表面生物膜的经济和环境影响，我们强调了在海洋工业和开发高效水处理系统膜方面探索较少的基于 QAS 的防污方法的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/b4775677c427/biomolecules-14-00957-g016.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/b4775677c427/biomolecules-14-00957-g016.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/363065399de8/biomolecules-14-00957-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/a15188c0cc3a/biomolecules-14-00957-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/c8b463327a30/biomolecules-14-00957-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/8734261c8de0/biomolecules-14-00957-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/6e12e6dc1b97/biomolecules-14-00957-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/eeaee1bf661a/biomolecules-14-00957-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/202011e0d4ab/biomolecules-14-00957-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6b8/11352365/b4775677c427/biomolecules-14-00957-g016.jpg

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