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金纳米棒的合成与表征及其在光热细胞损伤中的应用。

Synthesis and characterization of gold nanorods and their application for photothermal cell damage.

机构信息

Department of Chemistry, Hamdard University, Hamdard Nagar, New Delhi, India.

出版信息

Int J Nanomedicine. 2011;6:1825-31. doi: 10.2147/IJN.S11600. Epub 2011 Aug 31.

DOI:10.2147/IJN.S11600
PMID:22114472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3215149/
Abstract

BACKGROUND

Gold nanorods show a surface plasmon resonance (SPR) band at the near infra-red (NIR) region which enables them to produce heat on irradiation with a NIR laser. As a result of this, gold nanorods have the potential to be used as thermal therapeutic agents for selective damage to cancer cells, bacterial cells, viruses, and DNA.

METHODS

Gold nanorods with an aspect ratio of approximately 5 were prepared by exploiting the normal micellar route of a water/dioctyl sulfosuccinate (Aerosol-T)/hexane system. The shape and size of the gold nanorods were characterized by surface plasmon bands at 520 nm and 980 nm, and by atomic force microscopy and transmission electron microscopy.

RESULTS

The length of the gold nanorods was 100 nm and their diameter was 20 nm. X-ray diffraction analysis demonstrated that the gold nanorods formed were metallic in nature. The gold nanorods showed good photothermolysis activity.

CONCLUSION

Gold nanorods injected subcutaneously and irradiated with 980 nm laser caused injury to rat tissue, demonstrating that gold nanorods may be used to kill cancerous cells in tumor tissue.

摘要

背景

金纳米棒在近红外（NIR）区域显示出表面等离子体共振（SPR）带，这使它们能够在近红外激光照射下产生热量。因此，金纳米棒有可能被用作热疗剂，用于选择性地破坏癌细胞、细菌细胞、病毒和 DNA。

方法

通过利用水/二辛基琥珀酸磺酸钠（Aerosol-T）/正己烷体系的正常胶束途径，制备了纵横比约为 5 的金纳米棒。金纳米棒的形状和尺寸通过 520nm 和 980nm 的表面等离子体带以及原子力显微镜和透射电子显微镜进行了表征。

结果

金纳米棒的长度为 100nm，直径为 20nm。X 射线衍射分析表明，所形成的金纳米棒为金属性质。金纳米棒表现出良好的光热解活性。

结论

皮下注射金纳米棒并经 980nm 激光照射会对大鼠组织造成损伤，表明金纳米棒可用于杀死肿瘤组织中的癌细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/bebbc07c4ecd/ijn-6-1825f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/b4f1876ba142/ijn-6-1825f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/0ae609700eab/ijn-6-1825f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/355a36544d5c/ijn-6-1825f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/0c0cfdbca31e/ijn-6-1825f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/a84fd762a4d1/ijn-6-1825f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/bebbc07c4ecd/ijn-6-1825f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/b4f1876ba142/ijn-6-1825f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/0ae609700eab/ijn-6-1825f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/355a36544d5c/ijn-6-1825f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/0c0cfdbca31e/ijn-6-1825f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/a84fd762a4d1/ijn-6-1825f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/074b/3215149/bebbc07c4ecd/ijn-6-1825f6.jpg

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