Division of Cardiac Surgery, Heart Center Basel - Bern, University Hospital Basel, Basel, Switzerland.
Ann Thorac Surg. 2011 Dec;92(6):2235-9. doi: 10.1016/j.athoracsur.2011.05.012.
Established hemostatic devices can injure vessel wall integrity. LeGoo (Pluromed, Woburn, MA), a novel poloxamer gel with reverse thermosensitive properties, is a new device for temporary occlusion of blood vessels. The present study investigated the effects of LeGoo on vascular function and morphology.
The distal end of the human internal thoracic artery was used to assess vascular function of LeGoo-applied segments in organ bath experiments and by scanning electron microscopy.
After LeGoo application, both maximal contractile responses to noradrenaline and endothelium-dependent relaxant responses to acetylcholine were significantly reduced. Scanning electron microscopy showed areas of injured endothelium with exposure of subendothelial structures being in line with the functional changes.
Data suggested that application of LeGoo induced significant endothelial injury and deterioration of the smooth muscle in human internal thoracic arteries.
已有的止血设备可能会损伤血管壁的完整性。LeGoo（Pluromed，马萨诸塞州的沃本）是一种具有反向热敏特性的新型泊洛沙姆凝胶，是一种用于暂时阻断血管的新型装置。本研究旨在探讨 LeGoo 对血管功能和形态的影响。
用人的内乳动脉的远端进行血管功能评估，在器官浴实验和扫描电子显微镜下评估 LeGoo 应用段的功能。
LeGoo 应用后，去甲肾上腺素引起的最大收缩反应和乙酰胆碱引起的内皮依赖性舒张反应均显著降低。扫描电子显微镜显示受损的内皮区域，暴露的血管下结构与功能变化一致。
数据表明，LeGoo 的应用导致了人内乳动脉内皮的显著损伤和平滑肌功能的恶化。
