Department of Neurology, School of Medicine, Dicle University, Diyarbakir, Turkey.
Int J Neurosci. 2012 May;122(5):227-32. doi: 10.3109/00207454.2011.642039. Epub 2011 Dec 22.
The vascular calcification regulators and inflammatory markers including fetuin-A, osteopontin (OPN), and matrix Gla protein (MGP) may play an important role in the development of intracerebral hemorrhages (ICHs). So far, the relationship between these parameters and ICH has not been studied. Therefore, this study was designed to elucidate whether fetuin-A, MGP, and OPN are involved in the pathophysiology of ICH. The ICH group consisted of 27 consecutive patients with spontaneous ICH evaluated in the neurology intensive care unit within the first 24 hours from the onset of the stroke. The serum OPN levels were significantly increased in patients with ICH compared to the controls. On the other hand, the serum MGP and fetuin-A levels were significantly decreased in the patients with ICH in comparison to the controls. In the patients with ICH, the serum MGP levels of the nonsurvivors were statistically significantly lower than the MGP levels of the survivors. In conclusion, the change in serum fetuin-A, MGP, and OPN levels after ICH indicates that these parameters play a role in the pathophysiological processes leading to an ICH. Measurement of the serum MGP levels may also be of value to estimate mortality.
血管钙化调节剂和炎症标志物，包括胎球蛋白-A、骨桥蛋白（OPN）和基质 Gla 蛋白（MGP），可能在脑出血（ICH）的发展中起重要作用。到目前为止，这些参数与 ICH 的关系尚未得到研究。因此，本研究旨在阐明胎球蛋白-A、MGP 和 OPN 是否参与 ICH 的病理生理学过程。ICH 组包括 27 例连续评估的自发性 ICH 患者，这些患者在卒中发作后 24 小时内被收入神经病学重症监护病房。与对照组相比，ICH 患者的血清 OPN 水平显著升高。另一方面，与对照组相比，ICH 患者的血清 MGP 和胎球蛋白-A 水平显著降低。在 ICH 患者中，非幸存者的血清 MGP 水平明显低于幸存者的 MGP 水平。总之，ICH 后血清胎球蛋白-A、MGP 和 OPN 水平的变化表明这些参数在导致 ICH 的病理生理过程中起作用。测量血清 MGP 水平可能也有助于估计死亡率。
