Department of Biotechnology, Panjab University, Chandigarh, India.
Mol Cell Biochem. 2012 Mar;362(1-2):263-8. doi: 10.1007/s11010-011-1152-3. Epub 2011 Nov 25.
Prostate cancer is the second most diagnosed cancer in men next to skin cancer in the developed world. Risk of disease varies most prominently with age, ethnicity, family history, and diet. Genetic polymorphism of some genes has been implicated in increasing the risk. The XPD (Xeroderma pigmentosum group D) gene codes for a DNA helicase involved in transcription and nucleotide excision repair. The aim of this study is to evaluate the effect of XPD 751 Lys/Gln polymorphism on risk of prostate cancer on north Indian patients. Blood sample from 150 prostate cancer patients, 150 from Prostate Hyper Plasia and equal number of samples from healthy control groups was collected from North India. The polymerase chain reaction and restrictive fragment length polymorphism techniques were implemented. Statistically non-significant increase risk of prostate cancer was observed with patients having Gln/Gln genotype (OR 1.62, 95% CI).
在发达国家，前列腺癌是男性第二大常见癌症，仅次于皮肤癌。疾病风险最显著地与年龄、种族、家族史和饮食有关。一些基因的遗传多态性被认为会增加患病风险。XPD（着色性干皮病组 D）基因编码一种参与转录和核苷酸切除修复的 DNA 解旋酶。本研究旨在评估 XPD751 赖氨酸/谷氨酰胺多态性对北印度患者前列腺癌风险的影响。从印度北部采集了 150 例前列腺癌患者、150 例前列腺增生患者和相同数量的健康对照组的血液样本。采用聚合酶链反应和限制性片段长度多态性技术。统计分析显示，具有 Gln/Gln 基因型的患者患前列腺癌的风险略有增加（OR1.62，95%CI）。
