IVF Centers Prof. Zech-Salzburg, Salzburg, Austria.
J Assist Reprod Genet. 2012 Feb;29(2):131-5. doi: 10.1007/s10815-011-9680-z. Epub 2011 Nov 25.
To analyze the effects of embryo transfer (ET) quality on clinical pregnancy (CPR) and live birth delivery rates (LBDR).
In a retrospective study at a single, private infertility center between November 2005 and December 2009 one thousand fifty-five day-3 and day-5 ETs following IVF/ICSI/IMSI were evaluated. We analyzed the impact of an atraumatic ET with a soft catheter (ET 1), after external guidance (ET 2), after probing of the cervix with a stylet (ET 3), or after grasping the portio vaginalis with a tenaculum (ET 4) on CPR and LBDR.
The use of external guidance showed a significantly reduced LBDR as compared to an atraumatic ET (26.0% vs. 32.5%). The lowest CPR and LBDR were found in ET 4. The application of stylets in cases of difficult ETs was superior to the use of external guidance. No differences in miscarriages between ET 1-4 were noted.
Besides embryo culture and patient history, the quality of an ET might also have an important impact on pregnancy outcome. Techniques to ensure an atraumatic ET, such as mechanic uterine cavity length measurements, before starting treatment might help identify patients at risk for a difficult ET and lead to modified treatments, such as the primary use of a stylet. Limitation of study: retrospective analysis.
分析胚胎移植（ET）质量对临床妊娠（CPR）和活产分娩率（LBDR）的影响。
在 2005 年 11 月至 2009 年 12 月期间，在一家私人不孕不育中心进行了一项回顾性研究，评估了 1055 例 IVF/ICSI/IMSI 后第 3 天和第 5 天的 ET。我们分析了无创伤 ET 与软导管（ET1）、外部引导后 ET（ET2）、宫颈探子探查后 ET（ET3）或阴道穹窿钳夹后 ET（ET4）对 CPR 和 LBDR 的影响。
与无创伤 ET 相比，外部引导的 LBDR 显著降低（26.0%比 32.5%）。在 ET4 中发现 CPR 和 LBDR 最低。在困难 ET 中使用探子优于外部引导。在 ET1-4 之间，流产率无差异。
除了胚胎培养和患者病史外，ET 的质量也可能对妊娠结局有重要影响。在开始治疗前，采用确保无创伤 ET 的技术，如机械子宫腔长度测量，可能有助于识别 ET 困难的高危患者，并导致治疗方法的改变，如首选使用探子。研究的局限性：回顾性分析。
