Grishin O V, Basalaeva S V, Umantseva N D, Ustiuzhaninova N V, Grishin V G, Mitrofanov I M
Fiziol Cheloveka. 2011 Sep-Oct;37(5):77-83.
Pulmonary gas exchange, SpO2 and heart rate at 15-min hypoxia (respiration by air with 0.17; 0.15 and 0.13 oxygen fractions) have been investigated in 24 health subjects. It has been established, results of the group analysis and the results of the individual analysis had been differed. Reaction on hypoxia at the group analysis had been found only at 0.13 02 fraction. It was only hyperventilation. The individual analysis had revealed 4 types of reaction on hypoxia already at 0.17 and 0.15 02 fractions: (1) hyperventilation, (2) decrease of oxygen consumption, (3) increase of ventilation effectiveness, (4) increase of CO2 production. The mechanisms of last reaction are unknown, but we supposed it was connected with anaerobic metabolism. The reactions were detected at light hypoxia (0.17 and 0.15 oxygen fractions) in 90% health subjects when SpO2 decreased to 87-93%. The increase ventilation has been detected at hypoxia within respiration 0.13 oxygen in 60% subjects when SpO2 decreased to 83-87%, while other reactions were nearly absent.
对24名健康受试者进行了研究，观察他们在15分钟低氧（吸入氧气分数分别为0.17、0.15和0.13的空气）状态下的肺气体交换、血氧饱和度（SpO2）和心率。结果发现，组分析结果与个体分析结果存在差异。在组分析中，仅在氧气分数为0.13时发现对低氧的反应，且仅表现为过度通气。个体分析显示，在氧气分数为0.17和0.15时就已出现4种对低氧的反应类型：（1）过度通气；（2）氧耗降低；（3）通气效率增加；（4）二氧化碳产生增加。最后一种反应的机制尚不清楚，但我们推测它与无氧代谢有关。在轻度低氧（氧气分数为0.17和0.15）时，90%的健康受试者出现这些反应，此时SpO2降至87 - 93%。当氧气分数为0.13时进行呼吸低氧时，60%的受试者出现通气增加，此时SpO2降至83 - 87%，而其他反应几乎未出现。
