Gardner A M, Fox R H, Lawrence C, Bunker T D, Ling R S, MacEachern A G
Torbay Hospital, Devon, England.
J Bone Joint Surg Br. 1990 Sep;72(5):810-5. doi: 10.1302/0301-620X.72B5.2211762.
Following the discovery of a powerful venous pump in the foot that is activated by weight-bearing independently of muscular action, a pneumatic impulse device was developed to actuate this pump artificially. In a multicentre international trial the device was shown to reduce post-traumatic and postoperative swelling; pain also was alleviated. Evidence is also presented that dangerously high compartment pressures may be reduced to acceptable levels and fasciotomy avoided. We present an explanation of the clinical effects of activation of the venous footpump, based on recent improved understanding of the physiology of the microcirculation. The hyperaemic response that follows the liberation of endothelial-derived relaxing factor (EDRF) by sudden changes of pressure after weight-bearing or impulse compression is particularly important.
在发现足部存在一种强大的静脉泵，其在负重时被激活且独立于肌肉活动之后，人们开发了一种气动脉冲装置来人工驱动该泵。在一项多中心国际试验中，该装置被证明可减轻创伤后和术后肿胀；疼痛也得到缓解。还有证据表明，危险的高骨筋膜室压力可降至可接受水平，从而避免进行筋膜切开术。基于最近对微循环生理学的深入理解，我们对激活足部静脉泵的临床效果进行了解释。负重或脉冲压缩后压力突然变化导致内皮源性舒张因子（EDRF）释放后出现的充血反应尤为重要。
