Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611-3008, USA.
Urol Clin North Am. 2012 Feb;39(1):77-88. doi: 10.1016/j.ucl.2011.09.005. Epub 2011 Oct 13.
As men age, there is an increase in the frequency of pathologic diseases affecting the genitourinary tract. Most notable among these changes are the rising prevalence of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). The pathogenesis of these conditions seems to be multifactorial and includes age-related changes in the nervous system and neuroregulatory factors, such as nitric oxide and RhoA/Rho-kinase. Various pharmacologic agents that target these pathways, such as α-blockers and PDE-5is, underscore the contribution of neuroregulatory factors on the development of LUTS/BPH and ED.
随着男性年龄的增长，影响泌尿生殖系统的病理疾病的频率会增加。在这些变化中，最值得注意的是良性前列腺增生（BPH）和勃起功能障碍（ED）引起的下尿路症状（LUTS）的患病率上升。这些疾病的发病机制似乎是多因素的，包括神经系统和神经调节因子的年龄相关性变化，如一氧化氮和 RhoA/Rho-kinase。各种靶向这些途径的药物，如α-受体阻滞剂和 PDE-5is，强调了神经调节因子对 LUTS/BPH 和 ED 发展的贡献。
