Department of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
BMC Infect Dis. 2011 Nov 25;11:328. doi: 10.1186/1471-2334-11-328.
Rickettsioses are emerging infections in Sri Lanka as shown by the increase in the number of clinically diagnosed rickettsial patients being reported to the Epidemiology Unit, Sri Lanka. However, mapping the disease for the whole island with laboratory confirmed cases has not been previously carried out.
615 samples received from 23 hospital representing 8 provinces were tested using ELISA or IFA methods and clinical data was collected using a validated questionnaire.
Rash was found among more spotted fever seropositive patients than scrub typhus seropositive patients while the opposite was true for the presence of eschar. Spotted fever and scrub typhus was found in a geographically restricted manner. Consistent temporal patterns were seen for the presentation of patients with rickettsioses in Kandy and Kurunegala districts for 2009 and 2010.
This study expanded knowledge on the distribution of rickettsioses in Sri Lanka and their clinical profiles which in turn helps in the clinical diagnosis of these infections.
正如向斯里兰卡流行病学部门报告的临床诊断的立克次体患者数量不断增加所表明的那样，立克次体病在斯里兰卡呈新现感染。然而，以前没有使用实验室确诊病例对全岛进行疾病测绘。
使用 ELISA 或 IFA 方法检测了来自代表 8 个省的 23 家医院的 615 个样本，并使用经过验证的问卷收集了临床数据。
皮疹在斑疹热血清阳性患者中比恙虫病血清阳性患者更为常见，而焦痂的情况则相反。斑疹热和恙虫病呈局部地域分布。在 2009 年和 2010 年，康提和库鲁内格勒地区的立克次体病患者出现了一致的时间模式。
本研究扩大了对立克次体病在斯里兰卡的分布及其临床特征的认识，这反过来有助于这些感染的临床诊断。
