Neuroimmmunology Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT, United Kingdom.
J Neuroimmunol. 2012 Jan 18;242(1-2):78-83. doi: 10.1016/j.jneuroim.2011.11.003. Epub 2011 Nov 26.
Experimental autoimmune encephalomyelitis (EAE) is one of the major pre-clinical models of multiple sclerosis. Use of this model has led to some important observations that has benefited human health, but it must also be said that there are many poor-quality studies using EAE that add little to knowledge or understanding. The lack of quality of clinical trials in humans led to the introduction of publication guidelines that aimed to improve the quality and transparency of studies. Therefore, with a view of doing the same, the ARRIVE (Animals in research: Reporting in vivo experiments) guidelines were developed as a checklist of information required for publication of animal studies. Based on the ARRIVE guidelines, we provide guidance on acceptable data handling and indicate the minimal acceptable standard that should be adhered to when reporting and importantly refereeing all publications relating to EAE. This is designed to constructively improve the quality of published work and reduce the futile use of animals in research.
实验性自身免疫性脑脊髓炎（EAE）是多发性硬化症的主要临床前模型之一。该模型的使用带来了一些有益于人类健康的重要观察结果，但也必须指出，有许多使用 EAE 的低质量研究对知识或理解几乎没有贡献。人类临床试验质量的缺乏导致了发布指南的引入，旨在提高研究的质量和透明度。因此，为了达到同样的目的，ARRIVE（动物研究中的报告：体内实验）指南被开发为出版动物研究所需信息的清单。基于 ARRIVE 指南，我们提供了可接受的数据处理指南，并指出在报告和重要的参考所有与 EAE 相关的出版物时应遵守的最低可接受标准。这旨在建设性地提高已发表工作的质量，并减少动物在研究中的无谓使用。
