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在黎巴嫩阿拉伯人群中复制研究与 2 型糖尿病相关的 CDKAL1 和 CDKN2A/2B 基因的常见变异。

Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population.

机构信息

University Medical Center Rizk Hospital, Beirut, Lebanon.

出版信息

Diabetes Res Clin Pract. 2012 Feb;95(2):e37-40. doi: 10.1016/j.diabres.2011.11.002. Epub 2011 Nov 26.

DOI:10.1016/j.diabres.2011.11.002
PMID:22119613
Abstract

We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.

摘要

我们研究了 CDKAL1(rs7754840 和 rs7756992)和 CDKN2A/2B(rs10811661)变体与 T2DM 的关联。患者中 rs7754840 和 rs7756992 的 MAF 更高，并且在加性、显性和隐性模型下，两者均与 T2DM 相关。CDKAL1 rs7754840 和 rs7756992 但不是 CDKN2A/2B rs10811661 与黎巴嫩的 T2DM 相关。

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