哈萨克族人群中多态性遗传标记及其与2型糖尿病临床和代谢指标的关联。
Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population.
作者信息
Benberin Valeriy V, Vochshenkova Tamara A, Abildinova Gulshara Zh, Borovikova Anna V, Nagimtayeva Almagul A
机构信息
Medical Center Hospital of the President's Affairs Administration of the Republic of Kazakhstan, Nur-Sultan, 80 Mangilik El Avenue / E495 bld. 2, Nur-Sultan, 010000 Republic of Kazakhstan.
Gerontology Center, Medical Center Hospital of the President's Affairs Administration of the Republic of Kazakhstan, Nur-Sultan, 80 Mangilik El Avenue / E495 bld. 2, Nur-Sultan, 010000 Republic of Kazakhstan.
出版信息
J Diabetes Metab Disord. 2021 Jan 20;20(1):131-140. doi: 10.1007/s40200-020-00720-z. eCollection 2021 Jun.
BACKGROUND
Type 2 diabetes mellitus is a serious public health problem worldwide. The aim of the study was to analyze the relationship of eight polymorphic gene variants with the development of clinical-metabolic rates of type 2 diabetes mellitus inside Kazakh population.
MATERIALS AND METHODS
139 patients with type 2 diabetes mellitus and 100 patients in the control group were examined. Genotyping of polymorphisms of candidate genes was carried out on a next generation QuantStudio 12 K Flex unit.
RESULTS
Gene locus rs7901695 and rs7903146, gene locus , , and gene locus demonstrated statistically significant associations with glucose metabolism, lipid profile and body mass index (BMI) in type 2 DM inside the population. Statistically significant difference in anthropometric and biochemical measures of , and has not been revealed.
CONCLUSIONS
Genetic polymorphisms that influence pancreatic gland beta-cells insulin release and secretion associate with metabolic and anthropometric measures definitive for type 2 DM in Kazakh population.
背景
2型糖尿病是全球范围内严重的公共卫生问题。本研究旨在分析哈萨克族人群中8种基因多态性变异与2型糖尿病临床代谢率发展的关系。
材料与方法
对139例2型糖尿病患者和100例对照组患者进行检查。候选基因多态性的基因分型在新一代QuantStudio 12 K Flex设备上进行。
结果
基因位点rs7901695和rs7903146、基因位点、和基因位点在该人群的2型糖尿病中与糖代谢、血脂谱和体重指数（BMI）表现出统计学上的显著关联。未发现、和的人体测量和生化指标存在统计学上的显著差异。
结论
影响胰腺β细胞胰岛素释放和分泌的基因多态性与哈萨克族人群中2型糖尿病确定的代谢和人体测量指标相关。
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