Tharp B R
Division of Pediatric Neurology, Stanford University Medical Center, California 94305-5235.
J Clin Neurophysiol. 1990 Jul;7(3):302-14. doi: 10.1097/00004691-199007000-00002.
The EEG is an excellent method for measuring brain maturation in premature neonates. Characteristic patterns typify each conceptional age (CA) (age in weeks from conception) and allow the experienced reader to predict within +/- 2 weeks the infant's CA. This paper reviews from an historical perspective (beginning with Berger) the dramatic changes the EEG undergoes from early premature birth (CA, 26 weeks) to term (CA, 40 weeks). The important features of normal EEG development are discussed as well as the clinical significance of an apparent arrest or delay of the normal developmental process, the so-called "dysmature" pattern. It is proposed that close attention to the stage of brain maturation in normal and abnormal EEGs might allow more accurate timing of the brain insult in infants with neurological sequelae.
脑电图是测量早产新生儿脑成熟度的一种极佳方法。每个孕龄（CA）（自受孕起的周龄）都有典型的特征模式，使经验丰富的读者能够在正负2周内预测婴儿的孕龄。本文从历史角度（从伯杰开始）回顾了脑电图从极早产（孕龄26周）到足月（孕龄40周）所经历的巨大变化。文中讨论了正常脑电图发育的重要特征，以及正常发育过程明显停滞或延迟（即所谓的“发育不成熟”模式）的临床意义。有人提出，密切关注正常和异常脑电图中的脑成熟阶段，可能有助于更准确地确定患有神经后遗症婴儿脑损伤的时间。
