Department of Neurology, Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng District, 100730 Beijing, China.
Neurol Sci. 2012 Aug;33(4):911-3. doi: 10.1007/s10072-011-0849-0. Epub 2011 Nov 27.
Neuromyelitis optica (NMO) is an antibody-mediated disease with the target antigen being the water channel aquaporin-4 (AQP4). More than 90% of NMO patients have relapse. Optimal treatments to prevent recurrence have not been established. Previous reports suggest that interferon beta (IFNB) has not been effective in NMO. However, we present a case of NMO with positive anti-myelin oligodendrocyte glycoprotein (MOG)(27-38) IgG and anti-AQP4 IgG treated with IFNB-1a successfully. The effect of IFNB on NMO and the role of anti-MOG antibodies in NMO deserve further study.
视神经脊髓炎（NMO）是一种抗体介导的疾病，其靶抗原为水通道蛋白 4（AQP4）。超过 90%的 NMO 患者会复发。目前尚未确定预防复发的最佳治疗方法。既往报告显示干扰素-β（IFNB）对 NMO 无效。然而，我们报告了 1 例抗髓鞘少突胶质细胞糖蛋白（MOG）（27-38）IgG 和抗 AQP4 IgG 阳性的 NMO 患者，经 IFNB-1a 治疗后成功缓解。IFNB 对 NMO 的作用以及抗 MOG 抗体在 NMO 中的作用值得进一步研究。
