Department of Cell and Molecular Biology, Northwestern University's Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA.
J Struct Biol. 2012 Jan;177(1):14-23. doi: 10.1016/j.jsb.2011.11.017. Epub 2011 Nov 18.
Although intermediate filaments are one of three major cytoskeletal systems of vertebrate cells, they remain the least understood with respect to their structure and function. This is due in part to the fact that they are encoded by a large gene family which is developmentally regulated in a cell and tissue type specific fashion. This article is in honor of Ueli Aebi. It highlights the studies on IF that have been carried out by our laboratory for more than 40 years. Many of our advances in understanding IF are based on conversations with Ueli which have taken place during adventurous and sometimes dangerous hiking and biking trips throughout the world.
尽管中间丝是脊椎动物细胞的三大细胞骨架系统之一，但就其结构和功能而言，它们仍然是了解最少的。这部分是由于这样一个事实，即它们是由一个大的基因家族编码的，这些基因在细胞和组织类型中以特定的方式发育调节。本文是为了纪念 Ueli Aebi 而写的。它强调了我们实验室 40 多年来进行的 IF 研究。我们在理解 IF 方面的许多进展都是基于与 Ueli 的对话，这些对话是在世界各地充满冒险和有时危险的徒步旅行和骑自行车旅行中进行的。
