七种用于盆腔器官脱垂的不同阴道植入网片的单轴生物力学特性。
Uniaxial biomechanical properties of seven different vaginally implanted meshes for pelvic organ prolapse.
作者信息
Shepherd Jonathan P, Feola Andrew J, Abramowitch Steven D, Moalli Pamela A
机构信息
Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, University of Pittsburgh Medical Center, 300 Halket St., Pittsburgh, PA 15213, USA.
出版信息
Int Urogynecol J. 2012 May;23(5):613-20. doi: 10.1007/s00192-011-1616-8. Epub 2011 Nov 26.
INTRODUCTION AND HYPOTHESIS
Recently, numerous type I macroporous polypropylene vaginal meshes have been introduced into the market with little known of their differences.
METHODS
Seven vaginal meshes were obtained and loaded to failure (n = 5/type). Additional cyclic loading determined permanent deformation with submaximal loading.
RESULTS
The load elongation curves demonstrated a bilinear response with lower stiffness (N/mm), followed by higher stiffness. Ascend™ was the stiffest mesh in both regions of the load elongation curve (0.72 and 1.66 N/mm) with the lowest transition to higher stiffness (13.4%). Polyform™ had the highest failure load (53.8 N) while Ultrapro™ had the lowest (7.83 N). Novasilk™ (89.4%) and Ultrapro™ (87.9%) had the highest relative elongations at mesh failure while Ascend™ had the lowest (40.2%). Ascend™ had the least relative elongation after three protocols of cyclic loading (3.0%, 9.8%, and 9.7%).
CONCLUSIONS
Current vaginal meshes demonstrate marked variation in biomechanical characteristics which may impact the in vivo behavior.
引言与假设
最近，多种I型大孔聚丙烯阴道网片已投放市场，但对它们之间的差异却知之甚少。
方法
获取了七种阴道网片并加载至失效（每种类型n = 5）。额外的循环加载通过次最大加载来确定永久变形。
结果
载荷伸长曲线显示出双线性响应，先是较低的刚度（N/mm），随后是较高的刚度。Ascend™在载荷伸长曲线的两个区域都是最硬的网片（分别为0.72和1.66 N/mm），向较高刚度转变的比例最低（13.4%）。Polyform™的失效载荷最高（53.8 N），而Ultrapro™最低（7.83 N）。Novasilk™（89.4%）和Ultrapro™（87.9%）在网片失效时的相对伸长率最高，而Ascend™最低（40.2%）。经过三个循环加载方案后，Ascend™的相对伸长率最小（分别为3.0%、9.8%和9.7%）。
结论
目前的阴道网片在生物力学特性上表现出显著差异，这可能会影响其在体内的行为。
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