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NCBI 参考序列（RefSeq）：现状、新特性和基因组注释政策。

NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy.

机构信息

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

出版信息

Nucleic Acids Res. 2012 Jan;40(Database issue):D130-5. doi: 10.1093/nar/gkr1079. Epub 2011 Nov 24.

DOI:10.1093/nar/gkr1079
PMID:22121212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3245008/
Abstract

The National Center for Biotechnology Information (NCBI) Reference Sequence (RefSeq) database is a collection of genomic, transcript and protein sequence records. These records are selected and curated from public sequence archives and represent a significant reduction in redundancy compared to the volume of data archived by the International Nucleotide Sequence Database Collaboration. The database includes over 16,00 organisms, 2.4 × 0(6) genomic records, 13 × 10(6) proteins and 2 × 10(6) RNA records spanning prokaryotes, eukaryotes and viruses (RefSeq release 49, September 2011). The RefSeq database is maintained by a combined approach of automated analyses, collaboration and manual curation to generate an up-to-date representation of the sequence, its features, names and cross-links to related sources of information. We report here on recent growth, the status of curating the human RefSeq data set, more extensive feature annotation and current policy for eukaryotic genome annotation via the NCBI annotation pipeline. More information about the resource is available online (see http://www.ncbi.nlm.nih.gov/RefSeq/).

摘要

国家生物技术信息中心 (NCBI) 参考序列 (RefSeq) 数据库是一个基因组、转录本和蛋白质序列记录的集合。这些记录是从公共序列档案中选择和整理出来的，与国际核苷酸序列数据库合作组织存档的数据量相比，冗余度显著降低。该数据库包括超过 16000 种生物、2.4×10(6)个基因组记录、13×10(6)个蛋白质和 2×10(6)个 RNA 记录，涵盖原核生物、真核生物和病毒（RefSeq 版本 49，2011 年 9 月）。RefSeq 数据库通过自动分析、协作和手动整理的综合方法进行维护，以生成序列、其特征、名称以及与相关信息源的交叉链接的最新表示形式。我们在此报告最近的增长情况、人类 RefSeq 数据集整理的状态、更广泛的特征注释以及通过 NCBI 注释管道进行真核生物基因组注释的当前策略。有关该资源的更多信息可在线获取（请参见 http://www.ncbi.nlm.nih.gov/RefSeq/）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3835/3245008/4815fc46e440/gkr1079f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3835/3245008/4815fc46e440/gkr1079f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3835/3245008/4815fc46e440/gkr1079f1.jpg

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NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy.

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