Cetin Ilker, Kantar Aslı, Unal Sevim, Cakar Nilgun
Ankara Child Health, Hematology, Oncology Education and Research Hospital, Ankara, Turkey.
J Matern Fetal Neonatal Med. 2012 Sep;25(9):1564-8. doi: 10.3109/14767058.2011.644365. Epub 2012 Jan 23.
The aim of the study was to assess myocardial damage in infants due to perinatal hypoxia.
The findings of 29 infants with perinatal hypoxia and 20 healthy infants were compared. Blood gas analysis, serum lactate, cardiac troponin I (cTnI), troponin T (cTnT), creatine kinase-MB (CK-MB) and B-type natriuretic peptide (BNP) were evaluated. Echocardiography together with tissue Doppler imaging was performed.
cTnT, CK-MB and BNP were higher in patients at the first day. There were positive correlations between the left ventricular (LV) myocardial performance index (MPI) and cTnT at first day and also at first month. LV ejection fraction and fractional shortening were lower at first day and at first month in patients. Myocardial systolic (Sm) and diastolic (Em and Am) velocities at all segments were lower at first day, and interventricular septum Sm, LV Sm, LV Em, right ventricular Em and LV Am were still lower at first month in patients. Isovolumic relaxation time at all segments together with LV MPI was higher at first day, ejection time values were lower and MPI values were higher at all segments at first month in patients.
These findings demonstrated that the signs of myocardial damage due to perinatal hypoxia still present at first month.
本研究旨在评估围产期缺氧对婴儿心肌的损伤。
比较29例围产期缺氧婴儿和20例健康婴儿的检查结果。评估血气分析、血清乳酸、心肌肌钙蛋白I（cTnI）、肌钙蛋白T（cTnT）、肌酸激酶同工酶MB（CK-MB）和B型利钠肽（BNP）。同时进行超声心动图和组织多普勒成像检查。
患者第一天时cTnT、CK-MB和BNP水平较高。第一天及第一个月时左心室（LV）心肌性能指数（MPI）与cTnT之间呈正相关。患者第一天及第一个月时左心室射血分数和缩短分数较低。患者第一天时所有节段的心肌收缩期（Sm）和舒张期（Em和Am）速度均较低，第一个月时室间隔Sm、左心室Sm、左心室Em、右心室Em和左心室Am仍较低。患者第一天时所有节段的等容舒张时间及左心室MPI较高，第一个月时所有节段的射血时间值较低而MPI值较高。
这些研究结果表明，围产期缺氧所致心肌损伤的体征在第一个月时仍然存在。
