Ibrahim Doreya Mohamed, Mostafa Amany A, Korowash Sara Ibrahim
Biomaterials Department, National Research Centre, 12622 Dokki, Cairo, Egypt.
Chem Cent J. 2011 Nov 28;5(1):74. doi: 10.1186/1752-153X-5-74.
Synthetic multi-substituted hydroxyapatite nano powders containing silicon and or carbonate prepared by a wet chemical method. The process parameters are set up to allow the simultaneous substitution of carbonate and silicon ions in the place of phosphorus. The chemical and structural characterizations of the prepared powders are determined with the aid of; XRF, ICP, XRD and FTIR. The results show that, the ion substitution in the crystal lattice of HA caused a change in the unit cell dimensions and affected the degree of crystallization of the produced powders. The apatite formation abilityy of the prepared discs from the synthesized powders is determined by immersing in SBF solution for different periods. The degree of ion release was determined in the obtained solutions. The examined surface of the immersed discs under SEM and analyzed by CDS showed a more dense HA layer than those of un-substituted ones. The HA with the substituted silicon and carbonate ions, showed the highest solubility with greater rate of ion release, compared with carbonate-free powder. All prepared powders took sodium ion from the SBF solution during immersion, which was not recorded before.
通过湿化学法制备的含硅和/或碳酸盐的合成多取代羟基磷灰石纳米粉末。设置工艺参数以允许同时用碳酸盐和硅离子取代磷。借助XRF、ICP、XRD和FTIR对制备的粉末进行化学和结构表征。结果表明，HA晶格中的离子取代导致晶胞尺寸发生变化，并影响了所制备粉末的结晶度。通过将合成粉末制成的圆盘在SBF溶液中浸泡不同时间来测定其磷灰石形成能力。测定所得溶液中的离子释放程度。在SEM下检查浸泡圆盘的表面并通过CDS分析，结果表明其HA层比未取代的圆盘更致密。与无碳酸盐粉末相比，含取代硅和碳酸盐离子的HA显示出最高的溶解度和更高的离子释放速率。所有制备的粉末在浸泡过程中都从SBF溶液中摄取了钠离子，这是以前未记录到的。
