羟基磷灰石和硅取代羟基磷灰石生物陶瓷体内溶解过程的比较

Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics.

作者信息

Porter A E, Patel N, Skepper J N, Best S M, Bonfield W

机构信息

Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street, Cambridge CB2 3QZ, UK.

出版信息

Biomaterials. 2003 Nov;24(25):4609-20. doi: 10.1016/s0142-9612(03)00355-7.

DOI:10.1016/s0142-9612(03)00355-7

PMID:12951004

Abstract

The incorporation of silicate into hydroxyapatite (HA) has been shown to significantly increase the rate of bone apposition to HA bioceramic implants. However, uncertainty remains about the mechanism by which silicate increases the in vivo bioactivity of HA. In this study, high-resolution transmission electron microscopy was used to observe dissolution from HA, 0.8 wt% Si-HA and 1.5 wt% Si-HA implants after 6 and 12 weeks in vivo. Our observations confirmed that defects, in particular those involving grain boundaries, were the starting point of dissolution in vivo. Dissolution was observed to follow the order 1.5 wt% Si-HA>0.8 wt% Si-HA>pure HA and it was found to be particularly prevalent at grain boundaries and triple-junctions. These observations may help to explain the mechanism by which silicate ions increase the in vivo bioactivity of pure HA, and highlight the enhanced potential of these ceramics for biomedical applications.

摘要

已证明将硅酸盐掺入羟基磷灰石（HA）中可显著提高骨与HA生物陶瓷植入物的附着速率。然而，关于硅酸盐增加HA体内生物活性的机制仍存在不确定性。在本研究中，使用高分辨率透射电子显微镜观察了HA、0.8 wt% Si-HA和1.5 wt% Si-HA植入物在体内6周和12周后的溶解情况。我们的观察证实，缺陷，尤其是那些涉及晶界的缺陷，是体内溶解的起始点。观察到溶解顺序为1.5 wt% Si-HA>0.8 wt% Si-HA>纯HA，并且发现在晶界和三叉晶界处尤为普遍。这些观察结果可能有助于解释硅酸盐离子增加纯HA体内生物活性的机制，并突出了这些陶瓷在生物医学应用方面增强的潜力。