路易体痴呆和帕金森病痴呆的生活质量和盐酸美金刚的作用。
Quality of life and the effect of memantine in dementia with lewy bodies and Parkinson's disease dementia.
机构信息
Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
出版信息
Dement Geriatr Cogn Disord. 2011;32(4):227-34. doi: 10.1159/000334523. Epub 2011 Nov 25.
AIM
To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias.
METHODS
A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health.
RESULTS
Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure.
CONCLUSION
This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.
目的
调查路易体痴呆患者的生活质量（QOL）和盐酸美金刚治疗的效果。
方法
对 70 例帕金森病痴呆（PDD）或路易体痴呆（DLB）患者进行为期 24 周的随机对照研究的二次分析，使用根据世界卫生组织健康分类的照顾者评定的阿尔茨海默病（AD）QOL-阿尔茨海默病（AD）量表评定领域。
结果
基线 QOL 显示 DLB/PDD 中身体功能的评分低于环境因素。与安慰剂相比，美金刚治疗可显著改善整体生活质量，并改善总 QOL、身体功能和结构。
结论
本研究表明，盐酸美金刚可改善路易体痴呆患者的生活质量。我们还展示了可用于临床实践的重要 QOL 模式。
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