Yamashita Kazuto, Furukawa Erika, Itami Takaharu, Ishizuka Tomohito, Tamura Jun, Miyoshi Kenjirou
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
J Vet Med Sci. 2012 Apr;74(4):507-11. doi: 10.1292/jvms.11-0274. Epub 2011 Nov 25.
It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.
众所周知，尽管没有有意识的动作，但心率或动脉血压可能会因手术刺激而升高。然而，关于犬类中抑制肾上腺素能反应所需麻醉剂量的信息有限。本研究旨在比较犬类中预防自主反应（MAC-BAR）和有意识动作（MAC）所需的七氟醚最低肺泡浓度。通过判断犬对施加于牙龈的有害电刺激的反应，在5只比格犬中测定七氟醚MAC-BAR和MAC。七氟醚MAC-BAR显著高于MAC（3.33±0.48对2.10±0.28%，P=0.005）。这些结果表明，自主反应发生在不存在有意识动作的七氟醚麻醉浓度下。
