YAMASHITA Kazuto, IWASAKI Yasunori, UMAR Mohammed A, ITAMI Takaharu
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
J Vet Med Sci. 2009 Nov;71(11):1509-12. doi: 10.1292/jvms.001509.
It is well known that the minimum alveolar concentration (MAC) of inhalation anesthetic decreases with increasing age. However, there is limited information regarding the effect of age on MAC in dogs. This study was designed to determine the effect of age on sevoflurane MAC in dogs. MAC was determined in 6 young (2 years old) and 6 old beagle dogs (8 to 10 years old) under artificial ventilation. Anesthesia was induced via mask induction and maintained with sevoflurane in oxygen, and MAC was determined by using a tail clamp method. The sevoflurane MAC for the older dogs was significantly less than that for the younger dogs (1.86 +/- 0.29% vs 2.25 +/- 0.15%, P=0.007). The MAC of sevoflurane is profoundly affected by age in dogs.
众所周知，吸入麻醉药的最低肺泡浓度（MAC）会随着年龄的增长而降低。然而，关于年龄对犬类MAC的影响，相关信息有限。本研究旨在确定年龄对犬类七氟醚MAC的影响。在人工通气条件下，对6只年轻（2岁）和6只老年比格犬（8至10岁）测定MAC。通过面罩诱导麻醉，并使用氧气和七氟醚维持麻醉，采用尾夹法测定MAC。老年犬的七氟醚MAC显著低于年轻犬（1.86±0.29%对2.25±0.15%，P=0.007）。七氟醚的MAC在犬类中受年龄影响很大。
