Han P F, Pollock S H, Matthews H W, Johnson J
Experientia. 1979 May 15;35(5):586-7. doi: 10.1007/BF01960333.
Treatment of turkey liver fructose-1,6--bisphosphatase with penicillin G progressively inactivated the enzyme and desensitized the enzyme toward high substrate inhibition. The treatment also led to reduced sensitivity to AMP inhibition and the loss of cooperative interaction among AMP-binding sites. These altered properties were not reversed by dialysis, but were prevented when treatment with penicillin G was perfomed in the presence of substrate.
用青霉素G处理火鸡肝脏果糖-1,6-二磷酸酶会使该酶逐渐失活，并使该酶对高底物抑制作用脱敏。这种处理还导致对AMP抑制的敏感性降低以及AMP结合位点之间协同相互作用的丧失。这些改变的特性不能通过透析逆转，但在底物存在下进行青霉素G处理时可以防止。
