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[以肾病综合征为表现的霍奇金淋巴瘤:一例病例报告并文献复习]

[Hodgkin's disease revealed by a nephrotic syndrome: a case report with literature review].

作者信息

Nafil Hatim, Tazi Illias, Mahmal Lahoucine

机构信息

Service d'hématologie, CHU Mohamed Vi, Université Cadi Ayyad, Marrakech, Maroc.

出版信息

Ann Biol Clin (Paris). 2011 Nov-Dec;69(6):689-92. doi: 10.1684/abc.2011.0636.

Abstract

The association between paraneoplasic nephrotic syndrome and Hodgkin's disease is rare. We report a case of Hodgkin's lymphoma in a young female patient with nephrotic syndrome. A 40-year-old woman presented with the clinical symptoms of nephrotic syndrome, kidney biopsy revealed minimal change glomerulonephritis. A treatment with prednisone was started but the response was partial. Twenty-four months after the diagnostic of nephrotic syndrome was made, she presented prolonged fever and weight loss, the physical examination showed cervical lymphadenopathy, which lymph node biopsy revealed Hodgkin lymphoma of the nodular sclerosing type. The patient was treated for Hodgkin disease stage IVB with ABVD regimen, and was in complete remission of both Hodgkin's disease and nephrotic syndrome.

摘要

副肿瘤性肾病综合征与霍奇金病之间的关联较为罕见。我们报告一例患有肾病综合征的年轻女性患者的霍奇金淋巴瘤病例。一名40岁女性出现肾病综合征的临床症状,肾脏活检显示为微小病变性肾小球肾炎。开始使用泼尼松治疗,但反应不完全。在诊断肾病综合征24个月后,她出现持续发热和体重减轻,体格检查发现颈部淋巴结肿大,淋巴结活检显示为结节硬化型霍奇金淋巴瘤。该患者接受了ABVD方案治疗IVB期霍奇金病,霍奇金病和肾病综合征均完全缓解。

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