López-Aguilar E, González-Chirinos P, Fernández-Diez J, Rivera-Márquez H, Mendoza-Flores L, Cerecedo-Díaz F
Servicio de Oncología y Nefrología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, D.F., México.
Bol Med Hosp Infant Mex. 1993 Nov;50(11):828-31.
It is presented a child with Hodgkin's disease which at diagnosis present associated at nephrotic syndrome. Male of nine years old which present a ganglionic growing of left jugular chain of one year evolution without systemic symptoms and anasarca. Were underwent a ganglionic biopsy with histopathology report of Hodgkin's disease mixed cellular variety and renal biopsy with histopathology report of minimal change disease. The patient present remission of nephrotic syndrome in simultaneous form at the control of the disease. In the reported cases of nephrotic syndrome associated with Hodgkin's disease it not clear the physiopathology. In this patient were realized immunologic studies of renal tissues to treat to find a possible mechanism of action of the neoplastic cells on the basal glomerular membrane but we can not found.
本文介绍了一名患有霍奇金病的儿童,诊断时伴有肾病综合征。该患儿为9岁男性,左侧颈静脉链淋巴结肿大已有一年,无全身症状及全身性水肿。进行了淋巴结活检,组织病理学报告为混合细胞型霍奇金病,同时进行了肾活检,组织病理学报告为微小病变病。在疾病得到控制的同时,患者的肾病综合征出现缓解。在报道的与霍奇金病相关的肾病综合征病例中,其病理生理学尚不清楚。对该患者的肾组织进行了免疫学研究,试图找到肿瘤细胞对肾小球基底膜可能的作用机制,但未找到相关证据。