Transplantation Immunology Laboratory and Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Adelaide, South Australia, Australia.
J Leukoc Biol. 2012 Feb;91(2):217-28. doi: 10.1189/jlb.0711355. Epub 2011 Nov 28.
Non-human primates (NHP) are essential translational models for biomedical research. Dendritic cells (DC) are a group of antigen presenting cells (APC) that play pivotal roles in the immunobiology of health and disease and are attractive cells for adoptive immunotherapy to stimulate and suppress immunity. DC have been studied extensively in humans and mice but until recently, have not been well characterized in NHP. This review considers the available data about DC across a range of NHP species and summarizes the understanding of in vitro-propagated DC and in vivo-isolated DC, which is now established. It is clear that although NHP DC exist within the paradigm of human DC, there are important functional and phenotypic differences when compared with human DC subsets. These differences need to be taken into account when designing preclinical, translational studies of DC therapy using NHP models.
非人类灵长类动物（NHP）是医学研究中重要的转化模型。树突状细胞（DC）是一群抗原呈递细胞（APC），在健康和疾病的免疫生物学中发挥关键作用，是用于过继免疫治疗以刺激和抑制免疫的有吸引力的细胞。DC 在人类和小鼠中得到了广泛的研究，但直到最近，在 NHP 中的特征还不是很好。本综述考虑了一系列 NHP 物种中关于 DC 的现有数据，并总结了目前已建立的体外增殖的 DC 和体内分离的 DC 的认识。很明显，尽管 NHP 的 DC 存在于人类 DC 的范例中，但与人类 DC 亚群相比，存在重要的功能和表型差异。在使用 NHP 模型进行 DC 治疗的临床前转化研究设计时，需要考虑到这些差异。
