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罗库溴铵作为成人家族性肌营养不良患者电抽搐治疗的肌肉松弛剂。

Rocuronium as muscle relaxant for electroconvulsive therapy in a patient with adult-onset muscular dystrophy.

出版信息

J ECT. 2011 Dec;27(4):e63-4. doi: 10.1097/YCT.0b013e31821d3541.

Abstract

Adult-onset muscular dystrophy is an inherited myopathy characterized by a variable degree of progressive muscle weakness and degeneration. Although not usually fatal, significant muscle weakness results in an up-regulation of acetylcholine receptors on the less responsive postjunctional muscles. The resulting profound potassium release when these receptors are stimulated by the depolarizing muscle relaxant succinylcholine can result in potentially fatal cardiac arrhythmias. We report a case of electroconvulsive therapy safely administered in a 61-year-old man with adult-onset muscular dystrophy requiring muscle relaxation with rocuronium.

摘要

成人型肌肉萎缩症是一种遗传性肌病,其特征是肌肉无力和退化程度不同。尽管通常不会致命,但严重的肌肉无力会导致乙酰胆碱受体在反应迟钝的节后肌肉上上调。当这些受体被去极化肌肉松弛剂琥珀酰胆碱刺激时,会释放大量钾,从而导致潜在致命的心律失常。我们报告了一例电惊厥治疗在一位需要用罗库溴铵进行肌肉松弛的 61 岁成年型肌肉萎缩症男性中的安全应用。

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