Comprehensive Breast Cancer Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan.
Breast Cancer. 2013 Apr;20(2):152-8. doi: 10.1007/s12282-011-0317-y. Epub 2011 Nov 29.
Angiogenesis is a fundamental component of oncogenesis. In this study we provided morphologic evidence of vascularization by using power Doppler ultrasound to correlate the clinicopathologic features of tumorigenesis, ER/c-erbB-2 expression, and tumor grade in invasive breast carcinoma.
Three indices (VI, vascularization index; FI, flow index; VFI, vascularization flow index) were used to analyze 3D power Doppler ultrasound images from 168 patients with malignant breast carcinoma and to correlate their clinicopathologic features.
VI (the mean tumor vascularity) was correlated with ER negativity (p < 0.0029) and VFI (the overall perfusion) was correlated with ER positivity (p < 0.0029). HER2 positivity was statistically significantly correlated with tumor vasculature (VI, VFI) and tumor size/volume. FI (the mean blood flow volume) was significantly correlated with tumor size/volume, but VI was not. The univariate or multivariate logistic regression analysis also showed the reverse correlations between ER expression and tumor vascularity, and positive correlations between HER2 expression and tumor vascularity as well as tumor volume.
This morphologic evidence of vascularization is correlated with tumor angiogenesis and ER/c-erbB-2 co-expression, which could clarify the biology of breast cancer.
血管生成是肿瘤发生的基本组成部分。在这项研究中，我们使用能量多普勒超声提供了血管生成的形态学证据，以将肿瘤发生的临床病理特征、ER/c-erbB-2 表达和肿瘤分级与浸润性乳腺癌相关联。
使用 3 个指数（VI、血管指数；FI、血流指数；VFI、血管化血流指数）分析了 168 例恶性乳腺癌患者的 3D 能量多普勒超声图像，并将其与临床病理特征相关联。
VI（平均肿瘤血管密度）与 ER 阴性相关（p < 0.0029），VFI（整体灌注）与 ER 阳性相关（p < 0.0029）。HER2 阳性与肿瘤血管生成（VI、VFI）和肿瘤大小/体积呈统计学显著相关。FI（平均血流体积）与肿瘤大小/体积显著相关，但 VI 则不然。单因素或多因素逻辑回归分析也显示了 ER 表达与肿瘤血管生成之间的负相关，以及 HER2 表达与肿瘤血管生成和肿瘤体积之间的正相关。
这种血管生成的形态学证据与肿瘤血管生成和 ER/c-erbB-2 共表达相关，这可以阐明乳腺癌的生物学特性。
