Mader J T, Adams K R, Wallace W R, Calhoun J H
University of Texas Medical Branch, Galveston.
Infect Dis Clin North Am. 1990 Sep;4(3):433-40.
Mechanistically, hyperbaric oxygen (HBO) appears useful for the treatment of osteomyelitis. HBO increases the oxygen tension in infected tissue, including bone. An adequate oxygen tension is necessary for oxygen-dependent killing of organisms by the polymorphonuclear leukocytes and for fibroblast activity leading to angiogenesis and wound healing. HBO has a direct bacteriocidal or bacteriostatic effect on anaerobic organisms. In addition, HBO augments the killing of Pseudomonas aeruginosa by the aminoglycoside--tobramycin. At the University of Texas Medical Branch at Galveston, adjunctive HBO is used for the Cierny Mader stage 3B and 4B osteomyelitis.
从机制上讲，高压氧（HBO）似乎对骨髓炎的治疗有用。高压氧可增加包括骨骼在内的感染组织中的氧张力。足够的氧张力对于多形核白细胞对生物体进行氧依赖性杀伤以及对于导致血管生成和伤口愈合的成纤维细胞活性而言是必要的。高压氧对厌氧生物具有直接的杀菌或抑菌作用。此外，高压氧可增强氨基糖苷类药物妥布霉素对铜绿假单胞菌的杀伤作用。在加尔维斯顿的德克萨斯大学医学分校，辅助性高压氧用于Cierny-Mader 3B期和4B期骨髓炎。
