p53过表达对喉鳞状细胞癌的预后有影响。
p53 overexpression impacts on the prognosis of laryngeal squamous cell carcinomas.
作者信息
Jalali Mir Mohammad, Heidarzadeh Abtin, Zavarei Mansour Jamali, Sarmast Hadi
机构信息
Otolaryngology, Head and Neck Surgery Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Guilan, Iran.
出版信息
Asian Pac J Cancer Prev. 2011;12(7):1731-4.
OBJECTIVES
To investigate the prognostic implications of p53 expression in the surgical margins of laryngeal squamous cell carcinomas.
METHODS
Thirty one patients with T3-4N0M0 cancers with pathologically negative margins were analyzed by immunohistochemistry (IHC) to detect expression of p53.
RESULTS
The p53 positive rates by IHC in the surgical margin were 16.1% (5/31). In the p53 positive margin group, the recurrent rate was higher than those without (80% vs 19.2%, P = 0.006). Also, the median free of disease period in the p53 positive margin group was shorter than other group (22.2 vs 47.8 months, P < 0.0001).
CONCLUSIONS
We found that the overexpression of p53 can serve a prognostic role for both recurrence and disease-specific mortality in head and neck squamous cell carcinoma. p53 expression could stratify patients, in an easy and inexpensive way, according to their risk of local or regional recurrence.
目的
探讨p53表达在喉鳞状细胞癌手术切缘中的预后意义。
方法
对31例T3-4N0M0且病理切缘阴性的癌症患者进行免疫组织化学（IHC）分析，以检测p53的表达。
结果
手术切缘IHC检测的p53阳性率为16.1%（5/31）。在p53阳性切缘组中，复发率高于无p53阳性切缘组（80%对19.2%，P = 0.006）。此外，p53阳性切缘组的无病生存期中位数短于其他组（22.2对47.8个月，P < 0.0001）。
结论
我们发现p53的过表达可对头颈部鳞状细胞癌的复发和疾病特异性死亡率起到预后作用。p53表达可根据患者局部或区域复发风险，以简单且经济的方式对患者进行分层。
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