Fatima Saira, Arshad Sidra, Ahmed Zubair, Hasan Sheema H
Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan.
Asian Pac J Cancer Prev. 2011;12(7):1873-5.
Lymph adenopathy is of great clinical significance as underlying diseases may range from a treatable infectious etiology to malignant neoplasms. In fact it is also essential to establish that the swelling in question is a lymph node. Fine needle aspiration cytology (FNAC) plays a vital role in solving these issues, nowadays being recognized as a rapid diagnostic technique because of its simplicity, cost effectiveness, early availability of results, accuracy and minimal invasion. FNAC is particularly helpful in the work-up of cervical masses and nodules because biopsy of cervical adenopathy should be avoided unless all other diagnostic modalities have failed to establish a diagnosis.
To determine the epidemiological and cytomorphological patterns of enlarged neck nodes.
This retrospective observational study was performed at the Section of Histopathology, Aga Khan University Hospital (AKUH), Karachi, Pakistan.
Three Hundred and seventy seven (377) neck swelling specimens obtained over a period of two and a half years registered from different regions of Pakistan were selected. Data were analyzed using SPSS 17.
Of a total of 377 cases of FNAC performed on neck nodes, the most frequent cause of lymphadenopathy was found to be tuberculosis with 199 cases (52.7%), followed by reactive lymphoid hyperplasia with 61 cases (16.1%). Metastatic carcinoma was found to be the third most common cause with 33 cases (8.7%). A diagnosis of lymphoproliferative disorder was rendered in 21 cases (5.5%). Acute and chronic non-specific inflammation was seen in 16 cases (4.2%). In 47 cases (12%) FNAC was inconclusive.
In our study, the predominant cause of enlarged neck nodes was tuberculous lymphadenitis, followed by reactive lymphadenitis and malignant neoplasm, especially metastatic carcinoma and lymphoma. FNAC was helpful in establishing the diagnosis in approximately 98% of the cases.
淋巴结病具有重大临床意义，因为其潜在疾病范围可从可治疗的感染病因到恶性肿瘤。事实上，确定所讨论的肿胀是否为淋巴结也至关重要。细针穿刺细胞学检查（FNAC）在解决这些问题中起着至关重要的作用，如今因其操作简单、成本效益高、结果获取早、准确性高及侵入性小而被视为一种快速诊断技术。FNAC在颈部肿块和结节的检查中特别有用，因为除非所有其他诊断方法均未能确诊，否则应避免对颈部淋巴结病进行活检。
确定颈部淋巴结肿大的流行病学和细胞形态学模式。
本回顾性观察研究在巴基斯坦卡拉奇阿迦汗大学医院（AKUH）组织病理学科进行。
选取在两年半时间内从巴基斯坦不同地区登记的377例颈部肿胀标本。使用SPSS 17进行数据分析。
在总共377例对颈部淋巴结进行的FNAC病例中，发现淋巴结病最常见的原因是结核病，共199例（52.7%），其次是反应性淋巴组织增生，61例（16.1%）。转移性癌是第三大常见原因，33例（8.7%）。21例（5.5%）诊断为淋巴增生性疾病。16例（4.2%）可见急性和慢性非特异性炎症。47例（12%）FNAC结果不明确。
在我们的研究中，颈部淋巴结肿大的主要原因是结核性淋巴结炎，其次是反应性淋巴结炎和恶性肿瘤，尤其是转移性癌和淋巴瘤。FNAC在大约98%的病例中有助于确诊。
