Department of Dermatology, Medical Faculty, Yidız Technical University, Istanbul, Turkey.
Int J Dermatol. 2011 Sep;50(9):1071-4. doi: 10.1111/j.1365-4632.2010.04862.x.
Essential hyperhidrosis is a disease that expresses itself with excessive sweating in palmar, plantar, axillary, and craniofacial regions. The etiopathogenesis of the disease, which has particular importance because of leading to psychosocial morbidity, could have not been completely elucidated. In previous studies, it has been shown that oxidative stress might play a role in the pathogenesis.
Assessing the levels of trace elements such as Se, Zn, Cu, Fe, and Mg that have an important role in oxidative stress, as well as Ca and Mg that have an important role in membrane physiology, in patients with essential hyperhidrosis.
Blood samples taken from the patient group with essential hyperhidrosis (42) and the control group (37) were separated into plasma and erythrocytes, and the levels of the bioelements were measured by use of ICP-OES device.
Erythrocyte levels of Se, Fe, Cu, Zn, Ca, and Mg were detected significantly higher in patients with essential hyperhidrosis. Furthermore, plasma levels of Cu, Ca, and Mg were significantly lower in patients with essential hyperhidrosis. Plasma levels of Se, Fe, and Zn showed no statistical difference between two groups.
It was thought that the high levels of Cu and Fe in erythrocytes may play a role in increased intracellular oxidative stress, whereas the increase in Se and Zn levels may be secondary to increased oxidative stress. Low extracellular concentrations of Ca and Mg raise the thought that they play a role either enhancing the membrane excitability of eccrine sweat glands or influencing the autonomic nerve system.
The levels of trace elements, which were determined to be different from the control group, may play a role in the pathogenesis of essential hyperhidrosis either in direct relation with or without oxidative mechanisms.
原发性多汗症是一种表现为手掌、足底、腋窝和头面部过度出汗的疾病。由于导致精神社会发病率高，该疾病的病因发病机制尚未完全阐明。在以前的研究中，已经表明氧化应激可能在发病机制中起作用。
评估在原发性多汗症患者中具有重要氧化应激作用的微量元素（如硒、锌、铜、铁和镁）以及具有膜生理学重要作用的钙和镁的水平。
从原发性多汗症患者组（42 例）和对照组（37 例）采集血样，分为血浆和红细胞，并使用 ICP-OES 设备测量生物元素的水平。
原发性多汗症患者的红细胞硒、铁、铜、锌、钙和镁水平明显升高。此外，原发性多汗症患者的血浆铜、钙和镁水平明显较低。两组间血浆硒、铁和锌水平无统计学差异。
认为红细胞中高浓度的铜和铁可能在增加细胞内氧化应激中起作用，而硒和锌水平的增加可能是氧化应激增加的结果。细胞外钙和镁浓度降低提示它们可能通过增强汗腺的细胞膜兴奋性或影响自主神经系统来发挥作用。
与对照组相比，确定的微量元素水平可能通过直接或不通过氧化机制在原发性多汗症的发病机制中起作用。
