Canivet B, Le Cam A, Freychet P
Diabete Metab. 1979 Mar;5(1):17-9.
The aim of the present study was to determine whether or not somatostatin can directly affect amino acid transport and cyclic AMP (cAMP) release in isolated rat hepatocytes. Somatostatin at 1.5 microgram/ml (1mumol/l) had no effect on basal uptake of alpha-aminoisobutyric acid (AIB). Similarly, the peptide was without effect on basal cAMP release. Somatostatin exerted a slight but statistically not significant inhibitory effect on glucagon-stimulated AIB uptake and cAMP release. These observations do not support the possibility that somatostatin might directly interfere with hepatic glucose metabolism by altering the entry of amino acids into the liver and--or--by affecting the level of endogenous cAMP.
本研究的目的是确定生长抑素是否能直接影响分离的大鼠肝细胞中的氨基酸转运和环磷酸腺苷（cAMP）释放。1.5微克/毫升（1微摩尔/升）的生长抑素对α-氨基异丁酸（AIB）的基础摄取没有影响。同样，该肽对基础cAMP释放也没有作用。生长抑素对胰高血糖素刺激的AIB摄取和cAMP释放有轻微但无统计学意义的抑制作用。这些观察结果不支持生长抑素可能通过改变氨基酸进入肝脏的过程和/或通过影响内源性cAMP水平而直接干扰肝脏葡萄糖代谢的可能性。
