钙镁预防奥沙利铂相关神经毒性：这是否是疗效与毒性之间的权衡？
Calcium and magnesium prophylaxis for oxaliplatin-related neurotoxicity: is it a trade-off between drug efficacy and toxicity?
机构信息
Flinders Medical Centre, Adelaide, South Australia, Australia.
出版信息
Oncologist. 2011;16(12):1780-3. doi: 10.1634/theoncologist.2011-0157. Epub 2011 Nov 29.
Abstract
Oxaliplatin-based chemotherapy regimens are the current standard treatment in the management of colorectal cancer. Neurotoxicity is the major cause of treatment delay, dose reduction, and cessation of oxaliplatin. Evidence regarding the role of calcium and magnesium prophylaxis to prevent oxaliplatin-related neurotoxicity is conflicting and further randomized data are needed to answer this question accurately. The purpose of this paper is to provide a critical overview of various studies that have been conducted so far to evaluate the preventative role of calcium and magnesium prophylaxis against oxaliplatin-related neurotoxicity.
摘要
基于奥沙利铂的化疗方案是目前结直肠癌治疗的标准治疗方法。神经毒性是导致治疗延迟、剂量减少和停止奥沙利铂治疗的主要原因。关于钙和镁预防措施预防奥沙利铂相关神经毒性作用的证据存在争议，需要进一步的随机数据来准确回答这个问题。本文旨在对迄今为止进行的各种研究进行批判性综述，以评估钙和镁预防措施预防奥沙利铂相关神经毒性的作用。
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