自身抗原Ku与NF IV难以区分，NF IV是一种形成多聚体蛋白质-DNA复合物的蛋白质。
The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes.
作者信息
Stuiver M H, Coenjaerts F E, van der Vliet P C
机构信息
Laboratory for Physiological Chemistry, University of Utrecht, The Netherlands.
出版信息
J Exp Med. 1990 Oct 1;172(4):1049-54. doi: 10.1084/jem.172.4.1049.
Abstract
We have isolated a cDNA encoding the 84-kD subunit of NFIV. Tryptic peptide sequences were identified within the coding sequences, confirming its proper identity. The primary sequence of the protein is identical to that of the large subunit of the Ku autoantigen. A missing NFIV peptide sequence was identified within the sequence of the small subunit of Ku. In addition, the proteins are identical in immunological aspects. We suggest that the Ku and NFIV proteins are identical. This connection adds new biochemical data to our knowledge of the Ku autoantigen.
摘要
我们分离出了一个编码NFIV 84-kD亚基的cDNA。在编码序列中鉴定出了胰蛋白酶肽序列，证实了其正确的身份。该蛋白质的一级序列与Ku自身抗原大亚基的序列相同。在Ku小亚基的序列中鉴定出了一段缺失的NFIV肽序列。此外，这两种蛋白质在免疫学方面是相同的。我们认为Ku和NFIV蛋白是相同的。这种联系为我们对Ku自身抗原的认识增添了新的生化数据。
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