Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA.
Oral Dis. 2012 Apr;18(3):223-35. doi: 10.1111/j.1601-0825.2011.01876.x. Epub 2011 Dec 1.
The addition of genomic information to our understanding of oral disease is driving important changes in oral health care. It is anticipated that genome-derived information will promote a deeper understanding of disease etiology and permit earlier diagnosis, allowing for preventative measures prior to disease onset rather than treatment that attempts to repair the diseased state. Advances in genome technologies have fueled expectations for this proactive healthcare approach. Application of genomic testing is expanding and has already begun to find its way into the practice of clinical dentistry. To take full advantage of the information and technologies currently available, it is vital that dental care providers, consumers, and policymakers be aware of genomic approaches to understanding of oral diseases and the application of genomic testing to disease diagnosis and treatment. Ethical, legal, clinical, and educational initiatives are also required to responsibly incorporate genomic information into the practice of dentistry. This article provides an overview of the application of genomic technologies to oral health care and introduces issues that require consideration if we are to realize the full potential of genomics to enable the practice of personalized dental medicine.
基因组信息的加入推动了我们对口腔疾病的理解的重要变化。预计源自基因组的信息将促进对疾病病因的更深入了解，并允许更早的诊断，从而在疾病发作之前采取预防措施，而不是试图修复疾病状态的治疗。基因组技术的进步激发了人们对这种积极主动的医疗保健方法的期望。基因组测试的应用正在扩大，并且已经开始在临床牙科实践中找到应用。为了充分利用当前可用的信息和技术，牙科保健提供者、消费者和政策制定者必须了解基因组方法在口腔疾病中的应用，以及基因组测试在疾病诊断和治疗中的应用。还需要开展伦理、法律、临床和教育方面的倡议，以便负责任地将基因组信息纳入牙科实践。本文概述了基因组技术在口腔保健中的应用，并介绍了如果我们要充分发挥基因组学的潜力，实现个性化牙科医学实践的全部潜能，就需要考虑的问题。
