血清KL-6水平作为与结缔组织病相关的活动性或非活动性间质性肺炎的指标。

Serum KL-6 level as an indicator of active or inactive interstitial pneumonitis associated with connective tissue diseases.

作者信息

Doishita Satoshi, Inokuma Shigeko, Asashima Hiromitsu, Nakachi Shinichiro, Matsuo Yoshimi, Rokutanda Ryo, Kobayashi Shoko, Hagiwara Kiyofumi, Satoh Takeo, Akiyama Osamu

机构信息

Department of Allergy and Rheumatic Diseases, Japanese Red Cross Medical Center, Japan.

出版信息

Intern Med. 2011;50(23):2889-92. doi: 10.2169/internalmedicine.50.5866. Epub 2011 Dec 1.

DOI:10.2169/internalmedicine.50.5866

PMID:22129503

Abstract

OBJECTIVE

To elucidate the cut off levels of serum KL-6 indicating patients with interstitial pneumonitis (IP) and patients with active IP associated with connective tissue diseases (CTDs).

METHODS

CTD patients whose serum KL-6 level was measured were included. IP was diagnosed on the basis of medical records including XP/CT findings, and active IP was assumed in case that intervention for IP was newly added. The cut off levels were determined by receiver operating characteristic (ROC) curve analysis.

RESULTS

Among 240 (174 females) patients, 67 (42) had IP and 15 (9) had active IP. The ages of patients with and without IP, and with active IP and with inactive IP were 70.3±9.5 and 62.8±15.3, and 72.8±8.1 and 69.6±9.8, respectively. IP was significantly more prevalent in males and the elderly. The KL-6 levels were 990±90 and 301±12 U/mL in patients with and without IP, and 1,905±236 and 726±54 U/mL in those with active IP and with inactive IP, respectively. ROC curve analysis showed a cut off level of 509 U/mL for indicating IP, and that of 1,051-1,060 U/mL for indicating active IP.

CONCLUSION

A serum KL-6 level of higher than 500 U/mL is a marker of the presence of IP, and a level of higher than 1,000 U/mL is a marker of the presence of active IP associated with CTDs.

摘要

目的

阐明血清KL-6的截断水平，以用于指示间质性肺炎（IP）患者以及与结缔组织病（CTD）相关的活动性IP患者。

方法

纳入测定了血清KL-6水平的CTD患者。IP根据包括胸部X线/计算机断层扫描（CT）结果在内的病历进行诊断，若新增加了针对IP的干预措施，则假定为活动性IP。通过受试者工作特征（ROC）曲线分析确定截断水平。

结果

在240例（174例女性）患者中，67例（42例）患有IP，15例（9例）患有活动性IP。有IP和无IP患者的年龄，以及有活动性IP和无活动性IP患者的年龄分别为70.3±9.5岁和62.8±15.3岁，以及72.8±8.1岁和69.6±9.8岁。IP在男性和老年人中更为普遍。有IP和无IP患者的KL-6水平分别为990±90 U/mL和301±12 U/mL，有活动性IP和无活动性IP患者的KL-6水平分别为1,905±236 U/mL和726±54 U/mL。ROC曲线分析显示，指示IP的截断水平为509 U/mL，指示活动性IP的截断水平为1,051 - 1,060 U/mL。