Nakajima H, Harigai M, Hara M, Hakoda M, Tokuda H, Sakai F, Kamatani N, Kashiwazaki S
Institute of Rheumatology, Tokyo Women's Medical University, Japan.
J Rheumatol. 2000 May;27(5):1164-70.
To investigate the diagnostic value of the serum concentrations of KL-6, a mucinous glycoprotein expressed on type II pneumocytes, for interstitial pneumonia (IP) in various collagen diseases.
Serum KL-6 levels were measured by ELISA.
The mean values and the positive rates of serum KL-6 levels for patients with rheumatoid arthritis, systemic sclerosis, or polymyositis/dermatomyositis with IP were significantly higher than those without IP. Sensitivity, specificity, positive and negative predictive values of serum KL-6 level for IP associated with collagen diseases were 60.7, 98.9, 97.4, and 77.1%, respectively. The mean serum KL-6 level of patients with active IP was significantly (p = 0.0001) higher than that of patients with inactive IP. Serum KL-6 levels increased with the deterioration of IP, while the successful treatment of IP resulted in a significant decrease of these levels.
Serum KL-6 concentration levels are a useful marker for diagnosis and evaluation of the disease activity of IP associated with collagen diseases.
探讨血清中II型肺泡上皮细胞表达的黏液糖蛋白KL-6浓度对各种胶原病间质性肺炎（IP）的诊断价值。
采用酶联免疫吸附测定法（ELISA）检测血清KL-6水平。
类风湿关节炎、系统性硬化症或伴发IP的多发性肌炎/皮肌炎患者血清KL-6水平的平均值和阳性率显著高于无IP者。血清KL-6水平对胶原病相关IP的敏感性、特异性、阳性预测值和阴性预测值分别为60.7%、98.9%、97.4%和77.1%。活动性IP患者的血清KL-6平均水平显著高于非活动性IP患者（p = 0.0001）。血清KL-6水平随IP病情恶化而升高，而IP的成功治疗导致这些水平显著下降。
血清KL-6浓度水平是诊断和评估胶原病相关IP疾病活动度的有用标志物。
