Aging Research Center, Karolinska Institutet and Stockholm University, Gävlegatan 16, SE-113 30 Stockholm, Sweden.
Age Ageing. 2012 Mar;41(2):218-24. doi: 10.1093/ageing/afr144. Epub 2011 Nov 29.
the number of centenarians increases rapidly. Yet, little is known about their health and use of medications.
to investigate pharmacological drug use in community-dwelling and institutionalised centenarians compared with nonagenarians and octogenarians.
we analysed data on dispensed drugs for centenarians (n = 1,672), nonagenarians (n = 76,584) and octogenarians (n = 383,878) from the Swedish Prescribed Drug Register, record-linked to the Swedish Social Services Register. Multivariate logistic regression analysis was used to analyse whether age was associated with use of drugs, after adjustment for sex, living situation and co-morbidity.
in the adjusted analysis, centenarians were more likely to use analgesics, hypnotics/sedatives and anxiolytics, but less likely to use antidepressants than nonagenarians and octogenarians. Moreover, centenarians were more likely to use high-ceiling diuretics, but less likely to use beta-blockers and ACE-inhibitors.
centenarians high use of analgesics, hypnotics/sedatives and anxiolytics either reflects a palliative approach to drug treatment in centenarians or that pain and mental health problems increase into extreme old age. Also, centenarians do not seem to be prescribed cardiovascular drug therapy according to guidelines to the same extent as nonagenarians and octogenarians. Whether this reflects an age or cohort effect should be evaluated in longitudinal studies.
百岁老人的数量迅速增加。然而，人们对他们的健康状况和用药情况知之甚少。
调查与非百岁老人和八九十岁老人相比，社区居住和机构居住的百岁老人的药物使用情况。
我们分析了从瑞典处方药物登记处获得的数据，该数据记录了 1672 名百岁老人、76584 名非百岁老人和 383878 名八九十岁老人的药物使用情况，并与瑞典社会服务登记处进行了记录链接。使用多变量逻辑回归分析来分析年龄是否与药物使用相关，调整性别、生活状况和合并症后进行分析。
在调整分析中，与非百岁老人和八九十岁老人相比，百岁老人更有可能使用镇痛药、催眠药/镇静剂和抗焦虑药，但不太可能使用抗抑郁药。此外，百岁老人更有可能使用高天花板利尿剂，但不太可能使用β受体阻滞剂和 ACE 抑制剂。
百岁老人高使用镇痛药、催眠药/镇静剂和抗焦虑药，要么反映了对百岁老人药物治疗的姑息治疗方法，要么反映了疼痛和心理健康问题在极端老年时会增加。此外，百岁老人似乎没有按照指南规定的那样广泛使用心血管药物治疗，与非百岁老人和八九十岁老人相比。这是否反映了年龄或队列效应，应在纵向研究中进行评估。
