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瑞典新的处方药登记系统——药物流行病学研究的机遇及前六个月的经验

The new Swedish Prescribed Drug Register--opportunities for pharmacoepidemiological research and experience from the first six months.

作者信息

Wettermark Björn, Hammar Niklas, Fored Carl Michael, Leimanis Andrejs, Otterblad Olausson Petra, Bergman Ulf, Persson Ingemar, Sundström Anders, Westerholm Barbro, Rosén Måns

机构信息

Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden.

出版信息

Pharmacoepidemiol Drug Saf. 2007 Jul;16(7):726-35. doi: 10.1002/pds.1294.

Abstract

PURPOSE

To describe the content and potentials of the new Swedish national register on prescribed and dispensed medicines.

METHODS

The Swedish Prescribed Drug Register contains information about age, sex and unique identifier of the patient as well as the prescriber's profession and practice. Information regarding drug utilization and expenditures for prescribed drugs in the entire Swedish population was extracted from the first six months July-December 2005 and compared with total drug sales in the country including OTC and hospital use.

RESULTS

The total quantity of drugs sold in Sweden was 2666 million DDDs, corresponding to 1608 DDD/1000 inhabitants daily. The total expenditures were 1.6 billion Euro. The prescribed drugs, included in the register, accounted for 84% of the total utilization and 77% of the total expenditures. About half of all men and two-thirds of all women in the country purchased drugs. The proportion increased by age. The most common drugs for chronic treatment were diuretics among women (8.8% of the population) and antithrombotic agents among men (7.6%). Psychotropic drugs, corticosteroids and analgesics were more common among women, while men used antithrombotic agents, antidiabetic drugs, lipid lowering agents and ACE inhibitors to a greater extent.

CONCLUSIONS

The new register provides valuable data on exposure to drugs and is useful to study patterns of drug utilization. The possibilities for record linkage to other health registers gives from an international perspective good opportunities to explore drug and disease associations and the risks, benefits, effectiveness and health economical effects of drug use.

摘要

目的

描述瑞典新的处方药和配药国家登记册的内容及潜力。

方法

瑞典处方药登记册包含患者的年龄、性别和唯一标识符以及开处方者的职业和执业信息。从2005年7月至12月的前六个月中提取了瑞典全体人口的处方药使用和支出信息,并与该国包括非处方药和医院用药在内的药品总销售额进行了比较。

结果

瑞典销售的药品总量为2.666亿限定日剂量(DDD),相当于每日每1000名居民1608个DDD。总支出为16亿欧元。登记册中包含的处方药占总使用量的84%和总支出的77%。该国约一半的男性和三分之二的女性购买了药品。这一比例随年龄增长而增加。女性慢性治疗最常用的药物是利尿剂(占人口的8.8%),男性是抗血栓药物(7.6%)。精神药物、皮质类固醇和镇痛药在女性中更为常见,而男性更多地使用抗血栓药物、抗糖尿病药物、降脂药物和血管紧张素转换酶抑制剂。

结论

新登记册提供了关于药物暴露的宝贵数据,有助于研究药物使用模式。从国际角度来看,与其他健康登记册进行记录链接的可能性为探索药物与疾病的关联以及药物使用的风险、益处、有效性和健康经济影响提供了很好的机会。

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