可见分光光度法测定片剂中的阿立哌唑

Visible spectrophotometric method for the determination of aripiprazole in tablets.

作者信息

Jain R, Kashaw S K, Jain Rishab, Mishra P, Kohli D V

机构信息

Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar - 470 003, India.

出版信息

Indian J Pharm Sci. 2011 Jan;73(1):74-6. doi: 10.4103/0250-474X.89760.

DOI:10.4103/0250-474X.89760

PMID:22131625

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3224414/

Abstract

A simple, accurate and economic spectrophotometric method for the determination of aripiprazole in tablet formulation is proposed. In the present method acidic solution of the aripiprazole formed colored ion-association complexes with bromocresol green, soluble in chloroform. Yellowish orange chromogen showed λ(max) at 414 nm and obeyed Beer's law in the concentration range of 10-60 μg/ml. Statistical analysis and recovery studies validated the method. The proposed method is rapid, precise and accurate and can be applied for the routine estimation of aripiprazole in the laboratory.

摘要

提出了一种用于测定片剂制剂中阿立哌唑的简单、准确且经济的分光光度法。在本方法中，阿立哌唑的酸性溶液与溴甲酚绿形成有色离子缔合物，可溶于氯仿。橙黄色色原在414nm处显示λ（max），在10 - 60μg/ml浓度范围内符合比尔定律。统计分析和回收率研究验证了该方法。所提出的方法快速、精密且准确，可用于实验室中阿立哌唑的常规测定。